Are you talking about the DLS Iridium 6.3's? If so I would put the midbass in the doors, the midrange in the kicks and the tweeters in the apillars if possible, if not but them in the kick with the dome midrange.
This is no of the easier set to get to image and stage correctly do to the wide of axis response of the dome midrange, but it does take a little tuning to get them dialed in.