Never fuse any single wire of OFC greater than 300A as a general rule, with some exceptions. Could probably get away with more in shorter runs, but personally I would not chance it. So yeah, runs from front to back 300A. If you're running a single wire to the amp, I'd fuse it at 300A. You might be able to go up to 350A if you happen to blow it when pushing it, depending on the rating of the wire. See if you can find specs on shorter lengths of the wire you are using, or email the company to see what they rate a 5ft piece at. If you find dual inputs (toolmaker FTW) then I'd start with 150A-200A on each. Just what I would do.