The midrange on 6.3's have a better off axis response being domes than the cs365's. But if you are putting the 4's from the Profi's in angled kicks, nothing beats that larger driver playing lower. I personally like Rainbow tweets over DLS. Midbass is always a tossup, door dependent-both solid, natural. The Profis will get louder with less power from what I've come across.
Both great sets, cannot see anyone feeling they went wrong with either.
Also the cS365 from the Profi set (silk) or Profi Vanadium?