A 6 inch tube has a cross-sectional area of just a hair over 25 sq. in. The rule of thumb for a typical slot port is 10-16 sq. in of port area per cubic foot of net volume. For a slot port, that would put you at 60-100 sq in of port. According to test results, by utilizing aero ports, you can use up to 50% less port area with aero ports and still achieve the same airflow without restriction or turbulence. That would still put you at 30-50 sq. in of port area needed for a box of that volume. An 8" port would put you at 50 sq.in of port, but... it might require too long of port than you could fit into the box. If you used three 4" ports, that would put you at 37-38 sq. in of port area which would be perfect.
Just for reference, if you were to use a 6" aero port that was 16 inches long in a 6 cubic foot box, that would put your tuning at roughly 25Hz lol. I'm not sure what you're using this setup for, but that would be way too low for a reasonable car setup (unless you're just trying to impress people with crushing lows or using for a home-theater setup).
Can you give me the dimensions of the box: width, height, and depth? I can get a better idea for what would be possible as far as port options.