Thanks for the replies. @misfit138, I'd be willing to pick it up however this is something I'm not going to be doing for a few months so not looking to buy right now. What size amp should I be looking at getting? I know my Sony HU has 52W pre-amped channels, would it not be good enough? Roger on the 4x10's, there's opening's in the dash for 4x6's so maybe I could use those. Not sure if the truck didn't come with them and it's just got a standard dash for all S-10/Blazer models, if the owner before me sold them, or what. I was hoping to run across someone with an extended cab S-10 that's already swapped out their speakers and could offer advise from their experience, however, I'll take any advice I can get.
On a side note, I used to frequent these forum's quite often back around '05 and '06 when I first started messing around with my first '95 S-10. I kind of fell out when I joined the Navy back in the summer of '06, but I'm looking to get my new truck sounding good. So, I remembered this website and figured it helped me out a good deal back then and could help even more now.