well ill tell you what i did.hooked my 4 6.5 alpines into my 4 channel amp(100rms each). each speaker to its own channel. I have my small 4x6 sonys connected directly to my headunit(~50-75rms each). then i have my 2 subs wired in parallel and series down to 2ohms going to my mono amp.
with the alpine you could do 4 of the speakers to 4 of the channels and the sub to one channel. this will give you 75rms per speaker and 300rms for the sub according to the specs i found online. then you could run your tweeters from the jbl amp.
as for your original question
total rms doesnt change no matter what way you wire. if a speaker is 50rms itll take 50 rms. its the amp that matters about the wiring. also its series not serial