So here's my experience as of today on this exact topic.
I own a termlab with the clamp so I can check wattage.
Equipment is 2 DC Audio 2.0k amps, strapped at a half ohm per amp in the trunk of a 2003 Civic. Box dimensions are identical. The only differences in the boxes are single 15 was left side port, and the 2 12's have a center port. Both use a single, external, aero port.
Sub is/was DC Audio XL 15, and 2 DC XL 12's.
I tested as follows:
Car sealed, meter on the glass, keeping power under 2500 watts
Car sealed, meter on the glass, unlimited power
Drivers window down, meter in the kick, unlimited power
On 2300 watts, car sealed, 2 12's got me a .8db gain.
On 3500 watts, car sealed, I gained .7db.
Outlaw, I only gained .3db, BUT I ran out of time and wasn't able to do as much testing as I wanted/needed. I'm confident I'll get another .4 or so out of it. More testing with that later.
To the ear, there is ZERO difference. However, the car is more windy with the 2 12's. May just be port location, but the difference in felt wind is significant. Feels louder. Does NOT sound louder. IS louder on the meter.
If you're chasing numbers, in my experience, 2 12's are better with everything else being equal. I AM chasing numbers, so it's worth it.
If this is just a daily setup that you're not competing with, it won't make a bit of difference.