So is a ported box breathing slow or fast? And it has a huge hole it anyway, so I highly doubt it makes a diff...There is a huge gain in strength when you turn anything into a monocoque-like structure.
Also, have you ever tried breathing very fast or hard through certain fabrics or whatever and had a tough time, but when you breath easy and slow through it there's no problem? That's the concept behind aperiodic membranes, they become more resistive to higher velocities. MDF is porous, period. There are losses built into modeling programs that acknowledge facts like these.
As for strength, I've yet to have a box come apart, birch or MDF and I don't do any of that **** to them. My last wall had single layer panels in several places and had no problem doing a 60+...