Wow you can't get much more broad than this, really depends on the subwoofers. In theory yes you could power a couple twelves, I think you'd be better off though getting 1 12 inch subwoofer instead of two and sending it twice as much power as each one would get, then you'd be able to have a decent subwoofer in there. One rated for 300-350watts or so, and there are a lot of them out there.