Basically larger box = lower over all system compliance. Lower Qtc (overall compliance, i think that is what Qtc is) the flatter the responce curve anecho which means more low end output, less peaks, but also quieter. Also, the larger the volume the lower mechanical powerhandleing becomes.
In non audiophile terms, Large = Flatter and a tad quieter with less power handleing mechanically (means it will bottom out sooner) Small = Peaky, tad louder in certian ranges, greater mechanical powerhandleing (means it takes mroe power to bottom out the driver).
Because low end extension in an acoustic suspensionand IB set up is completel reliant on excursion, too large of a box wont be as loud as it potentially could be and your driver may bottom out on the lower notes where it wont on the higher notes and also wont be satisfyingly loud on the higher notes as well.
However, transient responce improves which means SQ improves slightly in all real music types (not monotone beats) and the responce curve is flatter.
Basically
Anal SQ Audiophiles = Large sealed/IB
SQ audiophiles = medium to small sealed
Almost everyone else = Ported/4th Order Bandpass
Thoes with room and Knowledge who dont even toil in CA.com except when bored = Transmission lines, Horns, 6th order bandpass, Excetera