the area of a circle can be calculated using this equation,A=3.14 x r x r
r= radius
a= area of port in cubic inches
so for a single 4" port the area is: 12.56cuin
for your application i would use a minimum of 2 4" ports which would give you an area of 25.1cuin.
now if you dont want any port noise what so ever then double that number, the problem with using more ports is that the port length also increase by a great margin.
now another thing you have to take into consideration is the location of the enclosure. because if the enclosure is in a trunk vehicle then you will rarely hear the port noise in the cab, and only hear it if you open the trunk lid and stand there while its blasting away.
so you can get away by using dual ports instead of 3 or 4 and not worry about the port noise even if its present, for the single fact that you wont hear it.