THE Thread

[ss3079 5,000+ posts]

You're so profound.

 

[bigluis 10+ year member]

how come lol doesnt count as a post?

 

[JAZN 5,000+ posts]

I have a question Steve, but this might be outside your area of expertise.

So drugs like Taxol are useful in treating cancer because they bind to microtubules and inhibit microtubule depolymerization, therefore stopping mitosis by preventing spindle breakdown. However, my question is, can actin be another suitable target for anti-cancer treatment?

 

[ss3079 5,000+ posts]

It's definitely not something I've ever studied.

I haven't really kept up to date with the drugs and cancer field, but I do believe that actin would be a suitable target.

You know that actin forms filaments which give structure to eurkaryotic cells as well as assist in cell growth and cell division - cancer is an uncontrolled growth, so why couldn't we give a drug that would specifically target actin?

I believe the question we have to ask is: just how do we specifically target actin?

I remember reading something about the University of Wisconsin-Madison finding organisms that have a symbiotic relationship with some sort of sea plants.

 

[JAZN 5,000+ posts]

Well the question doesn't ask how to specifically target actin so it is currently not a concern to me //content.invisioncic.com/y282845/emoticons/tongue.gif.6130eb82179565f6db8d26d6001dcd24.gif

Thanks for the help Steve, I would +rep you again if I could.

 

[JAZN 5,000+ posts]

Hey Steve, what causes muscle twitching?

 

[Chevillac 5,000+ posts]

Florida be good dre. I was going back and reading all the posts I missed. going out with a girl from last night in a few hours.

 

[Worlddre 5,000+ posts]

i expect nudes befor the night is over

anyone notice how lenny kracvitz is the man

 

[Chevillac 5,000+ posts]

Hmm, you know, its been kinda hard to get them to take pictures. I only have one so far.

 

[Worlddre 5,000+ posts]

liquor natures aphordisiac/ inhibitions remover

 

[ss3079 5,000+ posts]

Hey Steve, what causes muscle twitching?

A weak stimulus (electrical) to a muscle won't cause a contraction. Now if we increase the voltage and stimulate the muscle again, we will eventually figure out the threshold of that muscle fiber. Calcium is released into the cytoplasm and the sliding filament operation is activated - an extremely fast contraction + relaxation period occurs.

A ~ 2msec latent period between the stimulus and the actual twitch is observed. Excitation occurs during this period (tensioning of the muscle, excitation-contraction coupling, etc).

Once those elastic muscle components are taught, the contraction phase occurs (think external tension).

Of course, the contraction phase is short as the Calcium is pumped back into the sarcoplasmic reticulum. The Calcium levels fall ... and myosin will release the filaments and so the muscle tension drops.

I think I just went off about nothing.

 

[JAZN 5,000+ posts]

A weak stimulus (electrical) to a muscle won't cause a contraction. Now if we increase the voltage and stimulate the muscle again, we will eventually figure out the threshold of that muscle fiber. Calcium is released into the cytoplasm and the sliding filament operation is activated - an extremely fast contraction + relaxation period occurs.
A ~ 2msec latent period between the stimulus and the actual twitch is observed. Excitation occurs during this period (tensioning of the muscle, excitation-contraction coupling, etc).

Once those elastic muscle components are taught, the contraction phase occurs (think external tension).

Of course, the contraction phase is short as the Calcium is pumped back into the sarcoplasmic reticulum. The Calcium levels fall ... and myosin will release the filaments and so the muscle tension drops.

I think I just went off about nothing.

lol I'm sorry I didn't clarify. This was just a question for my benefit, not part of my homework (but I appreciate the science lesson anyways //content.invisioncic.com/y282845/emoticons/tongue.gif.6130eb82179565f6db8d26d6001dcd24.gif ). I was wondering what causes involuntary muscle twitching? (i.e. lack of sleep, stress, overworking a muscle, etc)

 

[ss3079 5,000+ posts]

Overworking/overloading can play a role in it - inorganic phosphate builds up when creatine phosphate is broken down and it has a role in muscle fatigue.

Many things can be the ultimate cause of muscle twitching - I assume you're talking about just sitting there and all of a sudden your bicep starts twitching out for a few seconds ... heat, toxins, prior overloading of the muscle, etc - lots of factors can play into it (think composition {ratio} of slow oxidative and fast glycolytic fibers in an athlete vs non-athlete). Nerve disorders, over-extension of muscle, sudden movements.

 

[Eldorado 5,000+ posts]

crap crap crap

I meant you give you a + rep steve, i clicked the wrong button but i was to late to stop the window

 

[ss3079 5,000+ posts]

crap crap crapI meant you give you a + rep steve, i clicked the wrong button but i was to late to stop the window

LOL - I was just going to post something regarding that.

I figured someone ****ed up, because those posts are great //content.invisioncic.com/y282845/emoticons/biggrin.gif.d71a5d36fcbab170f2364c9f2e3946cb.gif