Even if you have the physical clearance necessary, you'll also want to consider the loading effect on the diaphragm if you bring it too close to the floor. To avoid compression/loading/damping effects you want to have a minimum of 75% of the Sd open after full excursion is reached for the air immediately in front of the diaphragm to escape freely. The Sd of a 10" is roughly 57sq.in., so about 42.75sq.in. would be necessary per driver. That would mean roughly 3 inches of clearance on all four sides of the driver.
BUT...
Depending on how everything is set up, you could see gains in certain areas by taking advantage of slot loading effects experienced by a closer proximity to the floor. At the very least, don't make it so that the cone is just millimeters away from the floor at full excursion. That would be pretty restrictive and would actually limit output. It will also put you at risk of thermal compression or thermal failure. You can test this out by taking a driver in free-air and holding it level, very close the the floor, while playing low tones at high excursion. At a certain point you will be able to appreciate the restricted movement of the cone simply because it's too close to the floor.
Play around with it and you'll be able to come up with something.