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<blockquote data-quote="cotjones" data-source="post: 7663861" data-attributes="member: 573988">Oh OK well first lets look at it logically.In an established system, is a random change going to improve or hurt efficiency? Think of the car engine. Pick a random part and reverse it, What&#039;s the most likely outcome?Logically, there is not a reason that the most common mutation (Phenotype) wouldn&#039;t be negative. More so, we see it every day. Keep in mind, immune system response is NOT genetic mutation, and is NOT passed on to offspring.I have all kinds of studies that corroborate them, but you have to be a member of a university to see them for free.My area of interest is neuro. So let me give you a great example, I just did a study on this.Glioblastma Multiforme is the most common type of brain tumor (about 60% of all cases.) Of these glioblastomas, over 90% of them are caused by the loss of heterozygosity in a specific gene. Most of these occur as deletions in EGFR or NFKBIA coding regions. Leading to a overactive binding of the epidermal growth factor or lack of inhibition in the EGFR pathway. These events are mutually exclusive and are first generation mutations. These events occur in about 1 per 30,000 individuals. That alone is far more common than most events that can be considered a positive brain function mutation. And that&#039;s just one source of negative mutation</blockquote>

[QUOTE="cotjones, post: 7663861, member: 573988"] Oh OK well first lets look at it logically. In an established system, is a random change going to improve or hurt efficiency? Think of the car engine. Pick a random part and reverse it, What's the most likely outcome? Logically, there is not a reason that the most common mutation (Phenotype) wouldn't be negative. More so, we see it every day. Keep in mind, immune system response is NOT genetic mutation, and is NOT passed on to offspring. I have all kinds of studies that corroborate them, but you have to be a member of a university to see them for free. My area of interest is neuro. So let me give you a great example, I just did a study on this. Glioblastma Multiforme is the most common type of brain tumor (about 60% of all cases.) Of these glioblastomas, over 90% of them are caused by the loss of heterozygosity in a specific gene. Most of these occur as deletions in EGFR or NFKBIA coding regions. Leading to a overactive binding of the epidermal growth factor or lack of inhibition in the EGFR pathway. These events are mutually exclusive and are first generation mutations. These events occur in about 1 per 30,000 individuals. That alone is far more common than most events that can be considered a positive brain function mutation. And that's just one source of negative mutation [/QUOTE]

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