1 horsepower = 746 watts.
At 45 mph, a car needs about 20hp, or 14914 watts.
A decent audio system might need 750 watts or about 1 horsepower.
So, if you need 20 horsepower to cruise at 45 mph, and 1 horsepower more to run the audio system, then it takes about 5% more fuel to generate that...