Definitely the 4 12"!! I used to have a 94 blazer I had 4 12" infinity reference and the kicker kx1200.1 it was amazing. I had the 4 twelves pointed straight up with port straight up. I probably built 10 different boxes and tried all different setups. To me pointing up sounded best!!! Good luck man
2011 Impala LTZ w/ Bose
2 Custom Sundown Audio Zv3 in Custom Ported Enclosure
CDT HD-61A, CDT 6.5 for the rear
Big Three upgrade and all wiring from Audio Technix
XS Power D3100, XS Power D3400, Mechman 240A Billet Alt
Hmm, I would do the 4 12's for obvious cone area reasons. Now say 25-80 is a good deal of a range, in my opinion. I would rather see you bring that down around 60 hz. If you want SQ-ish setup then your mids/midbasses should play down that low. I think you may consider aeros here forsure.