Title:Raspberry ketone possesses anti-obesity activity
Source:Science Letter. (July 19, 2005): p1259.
Document Type:Brief article
Raspberry ketone possesses anti-obesity activity.
According to recent research from Japan, "Raspberry ketone [4-(4-hydroxyphenyl) butan-2-one; RK] is a major aromatic compound of red raspberry (Rubus idaeus). The structure of RK is similar to the structures of capsaicin and synephrine, compounds known to exert anti-obese actions and alter the lipid metabolism.
"The present study was performed to clarify whether RK helps prevent obesity and activate lipid metabolism in rodents. To test the effect on obesity, our group designed the following in vivo experiments: mice were fed a high-fat diet including 0.5, 1, or 2% of RK for 10 weeks; mice were given a high-fat diet for 6 weeks and subsequently fed the same high-fat diet containing 1% RK for the next 5 weeks."
"RK prevented the high-fat-diet-induced elevations in body weight and the weights of the liver and visceral adipose tissues (epididymal, retroperitoneal, and mesenteric)," said Chie Morimoto at Ehime University and collaborators in Japan. "RK also decreased these weights and hepatic triacylglycerol content after they had been increased by a high-fat diet. RK significantly increased norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase from the cytosol to lipid droplets in rat epididymal fat cells."
The researchers concluded, "RK prevents and improves obesity and fatty liver. These effects appear to stem from the action of RK in altering the lipid metabolism, or more specifically, in increasing norepinephrine-induced lipolysis in white adipocytes."
Morimoto and associates published their study in Life Sciences (Anti-obese action of raspberry ketone. Life Sci, 2005;77(2):194-204).
For additional information, contact Chie Morimoto, Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan. E-mail: [email protected]
Publisher contact information for the journal Life Sciences is: Pergamon-Elsevier Science Ltd., The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England.
Keywords: Ehime, Japan, Obesity Therapy, Weight Loss, Complementary and Alternative Medicine, Pharmaceutical and Drug Development, Diet and Nutrition, Lipolysis, Metabolism, Raspberry Ketone, Endocrinology.
This article was prepared by Science Letter editors from staff and other reports. Copyright 2005, Science Letter via NewsRx.com.
"Raspberry ketone possesses anti-obesity activity." Science Letter 19 July 2005: 1259. Academic OneFile. Web. 18 June 2012.
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