YES EXCELENT CHOICE!! with the boston, i have those myself, and you only need two channals for them. if you hhave rear speakers then you would need at least a 3 but most are 4. I have the 500/5 powering them now with 100 watts and they sound unbeleivable, but JL just came out with the 450/4 and i have a down payment on it now, Tweeter over here cant even get one in for display until mid march so i have to wait. But another good choice is the current 300/2 for the front two alone or the 300/4. If you wanted to know how to wire it, just connect the crossover that you get with the speakers to the amp then from the cross over wire your mid your 4 in and your tweet, you will have to play around wtih the settings to get it right though. good luck.
Crappy panasonic head unit, boston Pro Series 6.53, Boston RM9, 3 JL Audio 12 W3v2, JL Audio 500/1, JL Audio 500/5, optima battery, dynamat bulk kit, custom box, 1 fared capacator.