Re: with a sealed enclosure for two subs..
Well, you would wire them to the terminals the same way you would without them. If they are dual coice coil subs then you have to wire the voice coils together properly inside the box and to the terminals then wire the terminals.
However, I am not a fan of the terminals. I prefer to run the wire into the box through a hole and seal the hole after running the wires into the box. As for separate chambers...that is up to you. If you do, you lose a bit of space. Not a big deal if you have plenty of room to work with.
1996 Cavalier 2 door
1 - 18" Soundstream XXX
2 - Audioque AQ3500D.1